[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 6, Issue 2 (3-2018) ::
2018, 6(2): 363-377 Back to browse issues page
P53 researches and cancer therapy
Nasser Pouladi *, Roghayeh Dehghan, MohammadAli Hosseinpour Feizi, Sepehr Abdolahi, Masoumeh Valipour
Department of Biology, Faculty of Science, Azarbaijan Shahid Madani University, Tabriz, Iran , srna52@gmail.com
Abstract:   (445 Views)
Since the discovery of P53 in 1979 as a tumor antigen until today that has been established as an important tumor suppressor gene, over sixty four thousand paper and research reports were published in PubMed including this protein name. Although the results of these investigations have been helped to clarify the structure, function and regulation of P53, they also led to more ambiguities and questions about this protein. Identification of different isoforms of P53, the discovery of a P53 natural antisense (Wrap53) and recent findings about its different roles in processes such as longevity, aging and metabolism have made P53 remain attractive for study. Delivering the wild type P53 gene to p53 mutant cancer cells, introduction of small molecules that reactivate mutant p53 or suppress its important regulator, MDM2, are among the cancer therapies developed based on p53. The present article attempts to review the history and functions of p53 and discuss about the treatment strategies have been developed based on its antitumor properties.
Keywords: p53, DNA Damage, Tumor Suppressor Proteins, Neoplasms
Full-Text [PDF 682 kb]   (646 Downloads)    
Type of Study: Review | Subject: Animal
Received: 2017/10/4 | Accepted: 2018/03/11 | Published: 2018/04/18
Add your comments about this article
Your username or Email:


XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Pouladi N, Dehghan R, Hosseinpour Feizi M, Abdolahi S, Valipour M. P53 researches and cancer therapy. Genetic Engineering and Biosafety Journal. 2018; 6 (2) :363-377
URL: http://gebsj.ir/article-1-212-en.html

Volume 6, Issue 2 (3-2018) Back to browse issues page
دوفصل نامه علمی-پژوهشی مهندسی ژنتیک و ایمنی زیستی Genetic Engineering and Biosafety Journal
Persian site map - English site map - Created in 0.05 seconds with 31 queries by YEKTAWEB 3877