The COVID-19 outbreak has turned into a serious pandemic emergency, and presently is a global concern for humans worldwide. Lack of timely management and control of this disease could lead to a human catastrophe. Accordingly, various therapeutic interventions are being conducted for the COVID-19 remedy worldwide. The use of herbal medicine is one of the proposed remedy options in China and many other countries. The high homology of this viral genome with SARS (80%), and the presence of conclusive evidence of herbal medicine applications in the treatment and prevention of SARS are promising. This article focuses on the use of herbal medicine with potential application for COVID-19 remedy, and assessments of the inhibitory effects of these compounds on vital coronavirus proteins with molecular docking simulations. We also provide an opportunity to reveal the application of artificial enzymes for COVID-19 treatment. The use of artificial enzymes for the COVID-19 remedy is proposed for the first time in this study. Our molecular docking simulation results demonstrated that Glycyrrhetinic acid has an impressive inhibitory effect on all studied coronavirus proteins. Furthermore, carbonyl groups were identified as the key functional groups in the ligand-protein interactions. These can be subjected to the artificial enzyme designing for the COVID-19 remedy.